The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human Diseases
2023
Donato D’Angelo | Rosario Rizzuto
Calcium (Ca<sup>2+</sup>) ions act as a second messenger, regulating several cell functions. Mitochondria are critical organelles for the regulation of intracellular Ca<sup>2+</sup>. Mitochondrial calcium (mtCa<sup>2+</sup>) uptake is ensured by the presence in the inner mitochondrial membrane (IMM) of the mitochondrial calcium uniporter (MCU) complex, a macromolecular structure composed of pore-forming and regulatory subunits. MtCa<sup>2+</sup> uptake plays a crucial role in the regulation of oxidative metabolism and cell death. A lot of evidence demonstrates that the dysregulation of mtCa<sup>2+</sup> homeostasis can have serious pathological outcomes. In this review, we briefly discuss the molecular structure and the function of the MCU complex and then we focus our attention on human diseases in which a dysfunction in mtCa<sup>2+</sup> has been shown.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Directory of Open Access Journals
Découvrez la collection de ce fournisseur de données dans AGRIS