蛋黄磷脂与紫苏籽油复配对维持大鼠 血脂健康水平的影响Effect of combination of egg yolk phospholipid and perilla seed oil on maintaining healthy blood lipid level in rats

旨在为动物源性与植物源性脂质复配保健品的研发提供参考，以高脂饮食诱导建立SD大鼠混合型高脂血症动物模型，揭示蛋黄磷脂与紫苏籽油复配对维持大鼠血脂健康水平的影响。将50只雄性SD大鼠随机分为空白对照组，模型对照组和蛋黄磷脂与紫苏籽油复配受试物低、中、高剂量组，分析大鼠的体质量、肝脏指数、血脂水平、体成分以及肝脏中脂滴含量。结果表明：给予蛋黄磷脂与紫苏籽油复配受试物45 d，各组大鼠的体质量无显著差异，但受试物中、高剂量组大鼠的肝脏指数，各剂量组大鼠的血清总胆固醇（TC）水平以及高剂量组大鼠血清的甘油三酯（TG）水平均显著低于模型对照组，且TC和TG水平的降低趋势与受试物剂量之间存在显著的剂量-效应关系，而各剂量组大鼠血清的高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）无显著变化；各剂量组大鼠体内的脂肪占比较模型对照组均下降，瘦体质量占比上升，但均无显著差异；各剂量组大鼠的肝脏脂滴含量较模型对照组均极显著降低。综上，蛋黄磷脂与紫苏籽油复配受试物有助于维持大鼠的血脂健康水平。In order to provide reference for the research and development of health care products with animal and plant derived lipids, the mixed hyperlipidemia animal model of SD rats was established by the high-fat diet, and the effects of the combination of egg yolk phospholipid and perilla seed oil on blood lipid health level was revealed. 50 Male SD rats were divided into blank control group, model control group, high, medium and low dose groups of combination of egg yolk phospholipid and perilla seed oil, and the changes of body weight, liver index, blood lipid level, body composition and liver lipid droplet content in rats were analyzed. The results showed that after 45 d of administration of the test substance, the body weight of the rats in each group did not change significantly, but the liver index of the medium and high dose groups, the TC levels in each dose group, and the TG levels in the high dose group were significantly lower than those in the model control group. There was a significant dose-effect relationship between the decreasing trend of TC and TG levels and the dose of the test substance, while there was no significant change in HDL-C and LDL-C levels in each dose group. The proportion of body fat in the body composition of rats in each dose group decreased compared with the model control group, and the proportion of lean body mass increased, but there was no significant difference between them. The content of liver lipid droplets in each dose group was very significantly lower than that in the model control group. In summary, the combination of egg yolk phospholipid and perilla seed oil is helpful in maintaining the healthy blood lipid level of rats.