CHEMICAL PROPERTIES AND APPLICATIONS OF NITROPYRIDINES

Background. Pyridines are one of the most common heterocycles, the derivatives of which are widely used in pharmaceuticals, agrochemistry, and also in the production of new materials. Therefore, a comprehensive study of the chemical behavior of various pyridine derivatives will continue to be an urgent task of organic chemistry. This literature review is devoted to the systematization and analysis of the chemical properties of pyridine nitro derivatives, starting from the first half of the 20th century and up to the present. The paper considers both reactions proceeding through the nitro group (reduction under the action of various chemical agents, substitution, condensation) and reactions through the pyridine cycle. The main areas of application of nitropyridines are also shown. Purpose. Generalize and systematize the main types of reactions characteristic of nitropyridines, show the features of their chemical properties associated with the transformation of the nitro group, its effect on the mobility of substituents in the pyridine ring, as well as on the activity of the heterocycle as a whole. Materials and methods. To achieve the goal of the study, a review of the scientific literature was made on the main types of chemical reactions characteristic of pyridine nitro derivatives and the most significant areas of their application. Results. This paper summarizes the results of experimental studies on the chemical properties and application of nitropyridines from the beginning of the last century to the present. Conclusion. Thus, as a result of the analysis of sources devoted to the chemical properties and application of nitropyridines, a brief literature review was compiled, including the main types of reactions characteristic of the compounds under study, and their main areas of application were identified.