Detection of insertion/deletions (indels) of the <i>ATBF1</i> gene and their effects on growth-related traits in three indigenous goat breeds
2018
Z. Wei | Z. Wei | K. Wang | K. Wang | Y. Hui | H. Yan | H. Yan | H. Yan | H. Zhu | H. Zhu | L. Qu | L. Qu | C. Pan | H. Chen | X. Lan
<p>The AT motif-binding factor (<i>ATBF1</i>), also known as zinc finger homeobox 3 (<i>ZFXH3</i>), is necessary for activating the <i>POU1F1</i> gene; thus, the <i>ATBF1</i> gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the <i>ATBF1</i> gene were found in the Shaanbei white cashmere goat (SWCG; <i>n</i> = 581), the Guanzhong dairy goat (GZDG; <i>n</i> = 334) and the Hainan black goat (HNBG; <i>n</i> = 270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (<i>P</i> = 0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat <i>ATBF1</i> gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).</p>
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