Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair
2018
Junkui Sun | Zhengliang Luo | Guangxi Wang | Yuping Wang | Yisheng Wang | Margaret Olmedo | Massimo Max Morandi | Shane Barton | Christopher G. Kevil | Bing Shu | Xifu Shang | Yufeng Dong
Joint repair: Growing new cartilage from placental stem cells Stem cells derived from placental tissue may help in treating damaged joints, thanks to an improved method for encouraging them to form cartilage. Placenta-derived stem cells are readily available, as the placenta is usually discarded after birth. These stem cells can easily be grown into cartilage tissue in a laboratory, but not when transplanted. Researchers led by Yufeng Dong (Louisiana State University Health Sciences Center, Shreveport, USA) and Xifu Shang (Anhui Provincial Hospital, Hefei, China) treated stem cells with a naturally occurring protein, JAG1, which blocks the signal that prevents them from forming cartilage. They found that JAG1 increased the stem cells’ capacity for cartilage formation. When JAG1-stimulated stem cells were injected into a mouse model of joint disease, cartilage formation was improved, and joint inflammation was reduced.
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