Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model
2022
Gordana D. Vitaliano | Jae K. Kim | Marc J. Kaufman | Christopher W. Adam | Gonzalo Zeballos | Abinaya Shanmugavadivu | Sivan Subburaju | Jay P. McLaughlin | Scott E. Lukas | Franco Vitaliano
Vitaliano et al. show in mice that engineered clathrin triskelia (CT) conjugated to BDNF (BDNF-CT) and delivered intranasally increases hippocampal BDNF concentrations 400-fold above that achieved previously with intranasal BDNF alone. They also show that it enhance neurogenesis, synaptogenesis and cognition in a mouse model of HIV/neuroAIDS, highlighting its potential in regenerative medicine.
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