In Vivo Positive Magnetic Resonance Imaging of Brain Cancer (U87MG) Using Folic Acid-Conjugated Polyacrylic Acid-Coated Ultrasmall Manganese Oxide Nanoparticles
2021
Shanti Marasini | Huan Yue | Son-Long Ho | Ji-Ae Park | Soyeon Kim | Ji-Ung Yang | Hyunsil Cha | Shuwen Liu | Tirusew Tegafaw | Mohammad Yaseen Ahmad | Abdullah Khamis Ali Al Saidi | Dejun Zhao | Ying Liu | Kwon-Seok Chae | Yongmin Chang | Gang-Ho Lee
Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r<sub>1</sub>) value of 9.3 s<sup>−1</sup>mM<sup>−1</sup> (r<sub>2</sub>/r<sub>1</sub> = 2.2). Their application potential as cancer-targeting T<sub>1</sub> magnetic resonance imaging contrast agents was confirmed by their enhanced T<sub>1</sub> contrast enhancements at the brain cancer (U87MG) site upon intravenous administration to mice tails.
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