MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity
2017
David Latrasse | Teddy Jégu | Huchen Li | Axel de Zelicourt | Cécile Raynaud | Stéphanie Legras | Andrea Gust | Olga Samajova | Alaguraj Veluchamy | Naganand Rayapuram | Juan Sebastian Ramirez-Prado | Olga Kulikova | Jean Colcombet | Jean Bigeard | Baptiste Genot | Ton Bisseling | Moussa Benhamed | Heribert Hirt
Abstract Background Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level. Results Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase. Conclusions By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.
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