Standard: Human intestinal organoids

Yalong Wang; Hanqing Lin; Lianzheng Zhao; Fan Hong; Jie Hao; Zhen Zhang; Weiqi Sheng; Linhong Song; Chu-Xia Deng; Bing Zhao; Jiani Cao; Lei Wang; Liu Wang; Lingmin Liang; Wenli Kelly Chen; Chunping Yu; Zhijian Sun; Yingying Yang; Changlin Wang; Yong Zhang; Qiyuan Li; Ka Li; Aijin Ma; Tongbiao Zhao; Guoqiang Hua; Ye-Guang Chen

Standard: Human intestinal organoids

2023

Abstract Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications. “Human intestinal organoids” is the first guideline on human intestinal organoids in China, jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society: the Chinese Society for Stem Cell Research. This standard specifies terms and definitions, technical requirements, test methods, inspection rules for human intestinal organoids, which is applicable to quality control during the process of manufacturing and testing of human intestinal organoids. It was originally released by the Chinese Society for Cell Biology on 24 September 2022. We hope that the publication of this standard will guide institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.

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