A Candidate Gene Association Study for Economically Important Traits in Czech Dairy Goat Breeds
2021
Michaela Brzáková | Jana Rychtářová | Jindřich Čítek | Zuzana Sztankóová
Milk production is influenced by many factors, including genetic and environmental factors and their interactions. Animal health, especially udder health, is usually evaluated by the number of somatic cells. The present study described the effect of polymorphisms in the <i>ACACA</i>, <i>BTN1A1</i>, <i>LPL</i>, and <i>SCD</i> genes on the daily milk yield, fat, and protein percentages and somatic cell count. In this study, 590 White Shorthaired (WSH) and Brown Shorthaired (BSH) goats were included. SNP genotyping was performed by PCR-RFLP and multiplex PCR followed by SNaPshot minisequencing analysis. The linear mixed model with repeated measurement was used to identify the genetic associations between the studied genes/SNPs and chosen traits. All selected genes were polymorphic in the tested goat populations and showed significant associations with milk traits. Only <i>BTN1A1</i> (SNP g.599 A > G) showed a significant association with the somatic cell score. After Bonferroni correction, a significant effect of <i>LPL</i> g.300G > A on daily milk yield and fat percentage, <i>LPL</i> g.185G > T on protein percentage, and <i>LPL</i> G50C, <i>SCD</i> EX3_15G > A, and <i>SCD</i> EX3_68A > G on fat percentage was found. The importance of environmental factors, such as the herd-year effect, month of milking, and lactation order on all milk performance indicators was confirmed.
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