Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo
2023
Chłopecka Magdalena | Kiraga Łukasz | Crowley Kijan | Jank Michał | Latek Urszula | Mendel Marta | Karlik Wojciech
Due to the growing interest in the use of cannabinoids in supportive therapies, they are increasingly used together with anti-inflammatory drugs. Cannabinoids inhibit gastrointestinal motility, while steroidal and nonsteroidal anti-inflammatory drugs influence motility in other ways. The aim of the research was to study the interactions between cannabidiol (CBD) and these two classes of anti-inflammatory drugs in the context of gastrointestinal motility. Dexamethasone (DEX) was selected as a steroidal drug and diclofenac (DCF) as a nonsteroidal counterpart.
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