Ciliostasis of airway epithelial cells facilitates influenza A virus infection
2018
Yuguang Fu | Jie Tong | Fandan Meng | Doris Hoeltig | Guangliang Liu | Xiangping Yin | Georg Herrler
Abstract Porcine precision-cut lung slices (PCLS) were used to analyze the effect of the ciliary activity on infection of airway epithelial cells by influenza viruses. Treatment of slices with 2% NaCl for 30 min resulted in reversible ciliostasis. When PCLS were infected by a swine influenza virus of the H3N2 subtype under ciliostatic conditions, the viral yield was about twofold or threefold higher at 24 or 48 h post-infection, respectively, as compared to slices with ciliary activity. Therefore, the cilia beating not only transports the mucus out of the airways, it also impedes virus infection.
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