Activation mechanisms and ligands of G2 accumulation (G2A)
2015
Ichijo, Y. | Tomura, H.
To maintain homeostasis in the body, receptors sense internal and external environmental stimuli. G-protein-coupled receptors (GPCRs) mediate various cellular functions including its proliferation, adhesion and migration. They also play pivotal roles in development, homeostasis, inflammation and immunity. G2A was reported as a stress-inducible GPCR that prompts the cell cycle arrest at G2/M periods in murine bone marrow B lymphoid cells when serum-starved or DNA-damaged. In this review, we will discuss about ligands and functions of G2A.
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