Immunological study of an attenuated Salmonella typhimurium expressing ApxIA, ApxIIA, ApxIIIA and OmpA of Actinobacillus pleuropneumoniae in a mouse model
2015
Hur, J. ((Chonbuk National University, Jeonju (South Korea). College of Veterinary Medicine, Department of Bioactive Material Sciences), (Chonbuk National University, Jeonju (South Korea). College of Veterinary Medicine, Department of Veterinary Public Health)) | Eo, S.K. | Park, S.Y. | Choi, Y. | Lee, J.H.
Salmonella Typhimurium strain expressing the Actinobacillus pleuropneumoniae antigens, ApxIA, ApxIIA, ApxIIIA and OmpA, was previously constructed as a vaccine candidate for porcine pleuropneumonia. This strain was a live attenuated (delta lon delta cpxR delta asd)Salmonella as a delivery host and contained a vector containing asd. An immunological study of lymphocyte proliferation, T-lymphocyte subsets and cytokines in the splenocytes of a mouse model was carried out after stimulation with the candidate Salmonella Typhimurium by intranasal inoculation. The splenic lymphocyte proliferation and the levels of IL-4, IL-6 and IL-12 of the inoculated mice were significantly increased, and the T- and B-cell populations were also elevated. Collectively, the candidate may efficiently induce the Th1- and Th2-type immune responses.
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