Aberrant gene expression of heparanase in ventricular hypertrophy induced by monocrotaline in rats
2016
Ishiguro-Oonuma, T. (Ehime University, Toon, Ehime (Japan). Integrated Center for Sciences, Department of Biological Resources) | Suemoto, M. | Okada, M. | Yoshioka, K. | Hara, Y. | Hashizume, K. | Kizaki, K.
The gene expression levels of heparanase, matrix metalloproteinase 2 (MMP2) and MMP9 were examined in ventricles after treatment with monocrotaline (MCT) to induce cardiac hypertrophy in rats. Rats received a single intraperitoneal injection of MCT (60 mg/kg) or saline. Twenty-five days after the injection, the right ventricle and lung wet weights were increased in MCT-treated rats compared with the control. Histological analysis revealed cardiomyocyte hypertrophy in the right ventricle of MCT-treated rats. Northern blot hybridization showed that heparanase and MMP2 expression increased significantly in the right and left ventricles of MCT-treated rats, whereas MMP9 was not induced. These findings indicate that heparanase and MMP2 might play an important role in the development of MCT-induced cardiac hypertrophy.
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