Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma
2016
Michishita, M. (Nippon Veterinary and Life Science University, Musashino, Tokyo (Japan). Department of Veterinary Pathology) | Ohtsuka, A. | Nakahira, R. | Tajima, T. | Nakagawa, T. | Sasaki, N. | Arai, T. | Takahashi, K.
Feline mammary carcinomas are characterized by rapid progression and metastases. Vascular endothelial growth factor (VEGF) is a key regulator of tumor angiogenesis, proliferation and metastasis. The present study aimed to investigate the effects of a single drug therapy of bevacizumab on a xenograft model of feline mammary carcinoma expressing VEGF protein. Bevacizumab treatment suppressed tumor growth by inhibiting angiogenesis and enhancing apoptosis; however, it did not affect the tumor proliferation index. Thus, bevacizumab had anti-tumor effects on a xenograft model, and this may be useful for the treatment of feline mammary carcinoma.
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