Effects of Tankan compounds administration on immediate allergic reaction
2018
Goto, M. (Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki (Japan)) | Ishikawa-Takano, Y.
We reported that polymethoxyflavones of 'Tankan' (Citrus tankan Hayata) peal inhibited inflammatory cytokines production from antigen-induced splenocytes. In this study, we investigated the effects of the tankan peal extract and polymethoxyflavones in tankan peal on the allergic reactions. Firstly, allergic cutaneous reaction was reduced in tankan peals orally administered mice. And the treatment of polymethoxyflavones in tankan peals reduced antigen-specific immune responses of splenocytes and degranulation of RBL-2H3 cells. These results suggested that polymethoxyflavones of tankan peals inhibited allergic reactions.
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