Infection of porcine small intestinal enteroids with human and pig rotavirus A strains reveals contrasting roles for histo-blood group antigens and terminal sialic acids
2021
Guo, Yusheng | Adriana Candelero-Rueda, Rosario | Saifid, Linda Jean | Vlasova, Anastasia Nickolaevna | Arias, Carlos F. | Hanson, Juliette | Lee, Marcia V | Wood, Ronna S | Kick, Maryssa K | Liu, Mingde
The study established a porcine crypt-derived 3D intestinal enteroids (PIEs) culture system which contains all intestinal epithelial cells identified in vivo and represents a unique physiologically functional model to study RV-glycan interactions in vitro. Rotaviruses (RVs) are a leading cause of acute viral gastroenteritis in young children and livestock worldwide. Findings from the research indicate that targeting individual glycans for development of therapeutics may not yield uniform results for various RV strains. PIEs can serve as a model to study pathogen-glycan interactions and suggest that genetically distinct RVs have evolved diverse mechanisms of cell attachment and/or entry.
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