Bioaccumulation, oxidative stress, and neurotoxicity in Danio rerio exposed to different isotoptc compositions of uranium
2007
Barillet, Sabrina | Adam, Christelle | Palluel, Olivier | Devaux, Alain | Laboratoire de Radioécologie et d'Ecotoxicologie (IRSN/DEI/SECRE/LRE) ; Service d'Etude du Comportement des Radionucléides dans les Ecosystèmes (IRSN/DEI/SECRE) ; Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN) | Institut National de l'Environnement Industriel et des Risques (INERIS) | Laboratoire des Sciences de l'Environnement ; École Nationale des Travaux Publics de l'État (ENTPE) | Département Ecologie des Forêts, Prairies et milieux Aquatiques (DEPT EFPA) ; Institut National de la Recherche Agronomique (INRA)
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Afficher plus [+] Moins [-]anglais. Experiments were carried out on adult male zebrafish (Danio rerio) to assess early changes induced by waterborne exposure to different isotopic compositions of uranium (depleted uranium associated or not with U-233). Oxidative stress and neurotoxicity were selected as effect endpoints to characterize uranium chemo- and radiotoxicity. Catalase, glutathione peroxidase, and superoxide dismutase activities and total glutathione content of hepatic extracts, as well as brain acetylcholinesterase activity and uranium bioaccumulation, were measured. Oxidative stress induced by uranium exposure led to decreases in superoxide dismutase and catalase activity levels as well as total glutathione content in liver extracts. These perturbations were significantly more marked in U-233-exposed fish. Furthermore, significant increase in acetylcholinesterase activity was observed in brain extracts at the same level, whatever the isotopic composition of uranium.
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