Fungal Lytic Polysaccharide Monooxygenases (LPMOs): Biological Importance and Applications
2021
Várnai, Anikó | Hegnar, Olav | Horn, Svein | Eijsink, Vincent G.H. | Berrin, Jean-Guy | Norwegian University of Life Sciences (NMBU) | Biodiversité et Biotechnologie Fongiques (BBF) ; Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
International audience
Afficher plus [+] Moins [-]anglais. The many enzymes secreted by fungi to degrade plant biomass include a group of recently discovered redox enzymes called lytic polysaccharide monooxygenases (LPMOs). These LPMOs use oxidative chemistry to break glycoside bonds in cellulose and other polysaccharides and work synergistically with classical hydrolytic enzymes, such as cellulases. The number of LPMO-encoding genes in fungal genomes varies from zero to more than 50, suggesting multiple functional roles of these enzymes in fungi. The unique mode of action and high diversity of LPMOs are key to their potential in biomass valorization.
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