Exfoliative Toxins of Staphylococcus aureus
2017
Mariutti, Ricardo B | Rocha Tartaglia, Natayme | Seyffert, Nubia | de Paula Castro, Thiago Luiz | Arni, Raghuvir K | Azevedo, Vasco A. | Le Loir, Yves | Nishifuji, Koji | Multiuser Center for Biomolecular Innovation, IBILCE/UNESP | Science et Technologie du Lait et de l'Oeuf (STLO) ; Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST | Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG) | Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA) | Tokyo University of Agriculture and Technology (TUAT) | Shymaa Enany, Laura E. Crotty Alexande
Open Access Books » Life Sciences » Immunology and Microbiology
Afficher plus [+] Moins [-]anglais. Virulent strains of Staphylococcus aureus secrete exfoliative toxins (ETs) that cause the loss of cell‐cell adhesion in the superficial epidermis. S. aureus ETs are serine proteases, which exhibit exquisite substrate specificity, and their mechanisms of action are extremely complex. To date, four different serotypes of ETs have been identified and three of them (ETA,ETB and ETD) are associated with toxin‐mediated staphylococcal syndromes related tohuman infections leading to diseases of medical and veterinary importance.
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