Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep
2013
Hombach-Klonisch, Sabine | Danescu, Adrian | Begum, Farhana | Amezaga, Maria R. | Rhind, Stewart M. | Sharpe, Richard M. | Evans, Neil P. | Bellingham, Michelle | Cotinot, Corinne | Mandon-Pepin, Béatrice | Fowler, Paul A. | Klonisch, Thomas | Department of Human Anatomy & Cell Science; Department of Obstetrics, Gynecology & Reproductive Science ; University of Manitoba [Winnipeg] | Department of Human Anatomy & Cell Science ; University of Manitoba [Winnipeg] | Centre for Reproductive Endocrinology and Medicine, Institute of Medical Sciences ; University of Aberdeen | The James Hutton Institute | Queen's Medical Researche Institute ; The University of Edinburgh | College of Medical, Veterinary and Life Sciences [Glasgow] ; University of Glasgow | Biologie du développement et reproduction (BDR) ; École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS) | Centre for Reproductive Edocrinology and Medicine, Institute of Medical Sciences ; University of Aberdeen | Department of Human Anatomy & Cell Science; Department of Medical Microbiology & Infectious Diseases; Department of Surgery ; University of Manitoba [Winnipeg] | Welcome Trust, Natural Sciences and Engineering Research Council (NSERC) of Canada
Ewes were exposed to sewage sludge-fertilized pastures in a study designed investigate pre-conceptual and/or gestational exposure to environmental chemicals. The in utero impact on fetal thyroid morphology and function at day 110 (of 145) of pregnancy was then determined. Pre-conceptual exposure increased the relative thyroid organ weights in male fetuses. The number of thyroid follicles in thyroids of fetuses after pre-conceptual or gestational exposure was reduced. This correlated with an increase in Ki67 positive cells. Pre-conceptual exposure to sewage sludge reduced small blood vessels in fetal thyroids. Thyroid tissues of exposed fetuses contained regions where mature angio-follicular units were reduced exhibiting decreased immunostaining for sodium-iodide symporter (NIS). Fetal plasma levels of fT3 and fT4 in exposed animals, however, were not different from controls suggesting compensatory changes in the thyroid gland to maintain homeostasis in exposed fetuses. The regional aberrations in thyroid morphology may impact on the post-natal life of the exposed offspring.
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