Potential role of bioactive proteins and peptides derived from legumes towards metabolic syndrome

Garcés-Rimón, Marta; Morales, Diego; Miguel, Marta; Ministerio de Ciencia, Innovación y Universidades; Agencia Estatal de Investigación; Universidad Francisco de Vitoria

Potential role of bioactive proteins and peptides derived from legumes towards metabolic syndrome

2022

This article belongs to the Special Issue New Insights on Bioactive Compounds for the Prevention and Management of Metabolic Syndrome.

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Legumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible chronic diseases, specifically metabolic syndrome. An exhaustive revision of five relevant bioactivities (antioxidant, anti-inflammatory, antihypertensive, hypocholesterolemic -all of them linked to metabolic syndrome- and antitumoral) of proteins and peptides from legumes focused on isolation and purification, enzymatic hydrolysis and in vitro gastrointestinal digestion was carried out. The promising potential of bioactive hydrolysates and peptides from pulses has been demonstrated by in vitro tests. However, only a few studies validated these biological activities using animal models. No clinical trials have been carried out yet; so further research is required to elucidate their effective health implications.

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This research was funded by the Spanish Ministry of Education, Science and Universities (MICINN; AGL2017-89213) and Francisco de Vitoria University (UFV 2019-09). D.M. thanks to Spanish Ministry of Science and Innovation (MICINN) for the Juan de la Cierva Formación Fellowship (FJC2020-044585-I).

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Peer reviewed

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