Genetic assessment of African swine fever isolates involved in outbreaks in the Democratic Republic Of Congo between 2005 and 2012 reveals co-circulation of p72 genotypes I, IX and XIV, including 19 variants
2017
Mulumba-Mfumu, L. K. | Achenbach, J. E. | Mauldin, M. R. | Dixon, Linda | Tshilenge, C. G. | Thiry, Etienne | Moreno, Noelia | Blanco Lavilla, Esther | Saegerman, C. | Lamien, Charles E. | Diallo, A.
African swine fever (ASF) is a devastating disease of domestic pigs. It is a socioeconomically important disease, initially described from Kenya, but subsequently reported in most Sub-Saharan countries. ASF spread to Europe, South America and the Caribbean through multiple introductions which were initially eradicated—except for Sardinia—followed by re-introduction into Europe in 2007. In this study of ASF within the Democratic Republic of the Congo, 62 domestic pig samples, collected between 2005-2012, were examined for viral DNA and sequencing at multiple loci C-terminus of the B646L gene (p72 protein), central hypervariable region (CVR) of the B602L gene, and the E183L gene (p54 protein). Phylogenetic analyses identified three circulating genotypes I (64.5% of samples), IX (32.3%), and XIV (3.2%). This is the first evidence of genotypes IX and XIV within this country. Examination of the CVR revealed high levels of intra-genotypic variation, with 19 identified variants. © 2017 by the authors; licensee MDPI, Basel, Switzerland.
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