Influence of vehicle on kinetics of exogenous progesterone administered either by subcutaneous and intramuscular routes to sheep
2008
Contreras, Ignacio | Gómez-Brunet, A. | Encinas, Teresa | González De Bulnes, Antonio | Santiago Moreno, Julián | López Sebastián, Antonio | Contreras, Ignacio [0000-0001-5227-479X] | González De Bulnes, Antonio [0000-0002-0917-4475] | Santiago Moreno, Julián [0000-0001-5551-8120] | López Sebastián, Antonio [0000-0001-8695-7441]
This study aimed to determine the best vehicle and administration route for progesterone administration in sheep. In a first replicate, single intramuscular doses of 25 mg progesterone were administered to ewes previously ovariectomized, either in propylene glycol (group IM-PG, n = 6) or olive oil (group IM-OO, n = 5). In a second replicate, the same solutions of progesterone were administered subcutaneously to the same ewes (groups SC-PG, n = 6, and SC-OO, n = 5). In the present study, the best pharmacokinetic results of a single dose of 25 mg of progesterone were obtained, both using PG and OO as vehicles, by the subcutaneous route. Thus, progesterone remained in plasma for a longer time after subcutaneous administration in PG than in OO (t1/2β 60.65 ± 13.07 vs. 27.51 ± 3.59 h; P < 0.05); the mean residence time being higher in SC-PG than in SC-OO group (88.99 ± 18.36 vs. 41.04 ± 5.31 h; P < 0.05). However, both vehicles allowed maintained plasma levels ≥0.5 ng/ml for at least 30 h, so any of these treatments may be efficiently used for administration of exogenous progesterone. © 2007 Elsevier Ltd. All rights reserved.
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