Recent Advances in Aptamer-Based Biosensors for Bacterial Detection
2024
Léguillier, Vincent | Heddi, Brahim | Vidic, Jasmina | Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay) | DIM1Health | ANR-21-CE21-0009,Siena,Tests sensibles exploitant la reconnaissance de peptides et aptamères pour une détection sur site de cellules et spores bactériens dans le lait et la viande(2021)
International audience
Afficher plus [+] Moins [-]anglais. <div><p>The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical, electrochemical, and mass-sensitive analytical techniques, have garnered intense interest because of their versatility, cost-efficiency, and ability to exhibit high affinity and specificity in binding bacterial biomarkers, toxins, and whole cells. This review highlights the development of aptamers, their structural characterization, and the chemical modifications enabling optimized recognition properties and enhanced stability in complex biological matrices. Furthermore, recent examples of aptasensors for the detection of bacterial cells, biomarkers, and toxins are discussed. Finally, we explore the barriers to and discuss perspectives on the application of aptamer-based bacterial detection.</p></div>
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