Immunohistochemical expression of tryptase-chymase and mast cell heterogeneity in capsaicin-treated rat ovaries
2019
Tutuncu, Serife | Ertuğrul, Tuğrul
Red hot pepper, in the science of botany is a plant belonging to the Solanaceae family and known as Capsicum annuum. Capsaicin is the active ingredient in cayenne pepper. Mast cells are cells with intracytoplasmic granules in the connective tissue, showing metachromasia under appropriate conditions. The aim of the study is to observe mast cell localization and tryptase and chymase expression in ovaries of rats administered subcutaneous capsaicin at 1 mg / kg dose during postnatal development periods. Sixty female Spraque-Dawley rats (21 d old) were used. The rats were randomly divided into 3 groups (n=20 each) as pubertal, post pubertal and adult. Each group was subdivided into two groups. The first subgroup (control) was given no injections. The second subgroup (experiment) received subcutaneous injection of equal volume of capsaicin (1 mg/kg/d) for 7 weeks. Mast cells were observed in the cortex and medulla regions of the ovary during three different developmental periods, giving rise to tryptase and chymase positive reactions. In conclusion, low dose long-term capsaicin administration does not inactivate the presence of mast cells in the ovarian tissue, and the observation of fewer tryptase and chymase immunoreactive cells in the capsaicin-treated experimental groups led us to the conclusion that capsaicin positively affected mast cell heterogeneity in gonads.
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