Pegbovigrastim treatment resulted in an economic benefit in a large randomized clinical trial in grazing dairy cows
2022
Barca Tarigo, Joaquín | Schukken, Ynte Hein | Meikle, Ana | Chilibroste, Pablo | Bouman, Mette | Hogeveen, Henk | Barca Tarigo Joaquín, Universidad de la República (Uruguay). Veterinary Faculty. Department of Dairy Science and Technology | Schukken Ynte Hein, Wageningen University (Wageningen, The Netherlands). Department of Animal Sciences | Meikle Ana, Universidad de la República (Uruguay). Veterinary Faculty. Animal Endocrine and Metabolism Laboratory | Chilibroste Pablo, Universidad de la República (Uruguay). Agronomy Faculty. Animal Production and Pasture | Bouman Mette, Veterinary Practitioner (Colonia, Uruguay) | Hogeveen Henk, Royal GD (Deventer, The Netherlands)
This randomized controlled trial on 4 commercial grazing dairy farms investigated whether pegbovigrastim (PEG) treatment affected partial net return as calculated from milk revenues and costs for feed, medical treatments [clinical mastitis, uterine disease, and other diseases (i.e., any medical treatment that was not intended for clinical mastitis or uterine disease)], inseminations, and culling during a full lactation in grazing dairy cows. We also explored the effect of potential interactions of PEG treatment with parity, prepartum body condition score, and prepartum nonesterified fatty acids concentration on partial net return, milk revenues, and the costs mentioned above. Holstein cows were randomly assigned to 1 of the 2 following trial arms: a first PEG dose 9.4 ± 0.3 (mean ± standard error) days before the calving date and a second dose within 24 hours after calving (PEG: primiparous = 342; multiparous = 697) compared with untreated controls (control: primiparous = 391; multiparous = 723). The effect of PEG treatment on the outcomes of interest expressed per year was tested using general linear mixed models. Results are presented as least squares means ± standard error. Overall, PEG treatment increased the partial net return, resulting in an economic benefit per cow per year of $210 ± 100. The cost of treatment of clinical mastitis was lower for PEG treated cows compared with control cows ($9 ± 3). The largest nonsignificant difference was seen for the cost of culling; additionally, PEG treatment numerically reduced the cost of culling by $145 ± 77.
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