Mitochondrial dysfunction and its association with age-related disorders

Somasundaram, Indumathi; Jain, Samatha, M; Blot-Chabaud, Marcel; Pathak, Surajit; Banerjee, Antara; Rawat, Sonali; Sharma, Neeta, Raj; Duttaroy, Asim, K; Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research  ; Aix Marseille Université -Institut National de la Santé et de la Recherche Médicale -Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement; University of Oslo

Mitochondrial dysfunction and its association with age-related disorders

2024

Somasundaram, Indumathi | Jain, Samatha, M | Blot-Chabaud, Marcel | Pathak, Surajit | Banerjee, Antara | Rawat, Sonali | Sharma, Neeta, Raj | Duttaroy, Asim, K | Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) ; Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | University of Oslo (UiO)

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anglais. <div><p>Aging is a complex process that features a functional decline in many organelles. Various factors influence the aging process, such as chromosomal abnormalities, epigenetic changes, telomere shortening, oxidative stress, and mitochondrial dysfunction. Mitochondrial dysfunction significantly impacts aging because mitochondria regulate cellular energy, oxidative balance, and calcium levels. Mitochondrial integrity is maintained by mitophagy, which helps maintain cellular homeostasis, prevents ROS production, and protects against mtDNA damage. However, increased calcium uptake and oxidative stress can disrupt mitochondrial membrane potential and permeability, leading to the apoptotic cascade. This disruption causes increased production of free radicals, leading to oxidative modification and accumulation of mitochondrial DNA mutations, which contribute to cellular dysfunction and aging. Mitochondrial dysfunction, resulting from structural and functional changes, is linked to age-related degenerative diseases. This review focuses on mitochondrial dysfunction, its implications in aging and age-related disorders, and potential anti-aging strategies through targeting mitochondrial dysfunction.</p></div>

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Mots clés AGROVOC

adenosine triphosphate atp cns deoxyribonucleic acid dna mitochondrial dna oxidative phosphorylation reactive oxygen species rns tca tricarboxylic acid cycle un united nations

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Editeur

CCSD, Frontiers

D'autres materias

Translation of mitochondrial fission process 1 tfam; Mtssb; 8-hydrooxylamine; Mitochondrial uncoupling proteins; Mtor; Mammalian target of rapamycin; Mitochondrial transcription factor a ampk; 8-hydrooxylamine mtor; Réactive nitrogen species; Mtfp1; Mitochondrial transcriptional factor a; Mammalian target of rapamycin mtfp1; Mitophagy ros; Ap-1; Cytolytic t lymphocytes; Matrix metalloproteinases; Plk1 phosphorylates optineurin 8-ohdg; Sirtuin (silent mating type information regulation two homolog) 1; Damps; Pten induced putative kinase 1; 8-ohdg; Mitochondrial uncoupling proteins damps; Réactive nitrogen species mmp; Mitochondrial rna; Activator protein-1 ctl; Membrane permeability transition pores pgc-1a; Mitochondrial transcription factor a; Mitochondrial single strand binding protein tfam; Ctl; Peroxisome proliferator-activated receptor-gamma coactivator (pgc)-1 alpha pink-1; Mitochondrial dysfunction; Tfam; Mptp; Optn; Mitochondrial single strand binding protein; Mitochondrial transcriptional factor a rns; Activator protein-1; Mitochondrial rna dna; Sirtuin (silent mating type information regulation two homolog) 1 ucps; Ampk; Matrix metalloproteinases ap-1; Pgc-1a; Pink-1; Peroxisome proliferator-activated receptor-gamma coactivator (pgc)-1 alpha; Amp-activated protein kinase; Tricarboxylic acid cycle oxphos; Plk1 phosphorylates optineurin; Deoxyribonucleic acid un; Membrane permeability transition pores; Chromosomal aberrations; Amp-activated protein kinase sirt1; Reactive oxygen species mtrna; Oxphos; Mtrna; Central nervous systems; Damageassociated molecular patterns; Ros production; Oxidative phosphorylation atp; Cytolytic t lymphocytes mptp; Pten induced putative kinase 1 optn; [sdv]life sciences [q-bio]; Ucps; Damageassociated molecular patterns cns; Translation of mitochondrial fission process 1; Adenosine triphosphate mtssb; United nations tca; Sirt1; Mmp

Langue

anglais

Licence

http://creativecommons.org/licenses/by/, info:eu-repo/semantics/OpenAccess

ISSN

04965687

Type

Journal Article; Journal Part; Journal Article; Journal Part

Source

ISSN: 1664-042X, Frontiers in Physiology, https://amu.hal.science/hal-04965687, Frontiers in Physiology, 2024, 15, ⟨10.3389/fphys.2024.1384966⟩

Sur AGRIS depuis: 2025-03-19

Date de modification: 2025-10-24

Format: Dublin Core

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Cette notice bibliographique a été fournie par Institut national de la recherche agronomique

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DOI https://amu.hal.science/hal-04965687 https://amu.hal.science/hal-04965687v1/document https://amu.hal.science/hal-04965687v1/file/127%20Mitochondrial%20dysfunction%20and%20its.pdf

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Mitochondrial dysfunction and its association with age-related disorders

2024

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