Aluminium hydroxide-induced granulomas in pigs
2005
Valtulini, S. | Macchi, Cécile, Marie, Odile | Ballanti, P. | Cherel, Yan | Laval, A. | Theaker, J.M. | Bak, M. | Ferretti, E. | Morvan, Hervé | DVM Azienda Agricola Floria ; Partenaires INRAE | Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] (UNIROMA) | Développement et Pathologie du Tissu Musculaire (DPTM) ; Institut National de la Recherche Agronomique (INRA)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | Southampton University Hospitals NHS Foundation Trust | Odense University Hospital (OUH) | Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" (IZSLER) | Laboratoire de Développement et d'Analyses ; Partenaires INRAE
International audience
Afficher plus [+] Moins [-]anglais. The effect of intramuscular injection of 40 mg/2 ml aluminium hydroxide in the neck of pigs was examined in a number of ways. The investigation followed repeated slaughterhouse reports, according to which 64.8% of pigs from one particular farm were found at slaughter to have one or more nodules in the muscles of the neck (group slaughtered). The pigs had been injected with a vaccine containing 40 mg/2 ml dose of aluminium hydroxide as adjuvant. Research consisted of two phases: first, an epidemiological study was carried out, aimed at determining the risk factors for the granulomas. The results indicated that the vaccine was to be held responsible for the formation of granulomas. A clinical trial was then performed to further substantiate the initial hypothesis, by comparing pigs, which were aseptically inoculated twice with either the original vaccine or the adjuvant alone (groups vaccine and adjuvant) to pigs inoculated twice with apyrogenic bi-distilled water (group water) and to pigs inoculated once with the adjuvant and once with apyrogenic bi-distilled water (group adjuvant/water). Both studies agreed in their conclusions, which indicate that the high amount of aluminium hydroxide was the cause of the granulomas.
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