THE INFLUENCE OF WHOLE SONICATE BRUCELLA ABORTUS ANTIGEN ON THE CANDIDA ALBICANS INFECTION IN MICE
2009
M.J | S.S | I.A | Al-Oubaidy | Alwan | Al-Zubaidy
The aim of this study is to evaluate the effect of immunization with whole sonicate Brucella abortus antigen on the mice infected with Candida albicans, for that, Twenty one white mice ,both sexes, average weight 20-24g, were divided randomly into (3) equal groups. First group immunized with (0.5)ml of sonicated brucella antigen, two doses, 10 days interval, skin test was done 27 days post-vaccination, 2nd group and 3rd groups served as positive and negative control group respectively. (30) days post-vaccination, 1st and 2nd groups were challenged with (0.5)ml of inoculums (1X10yeast/ml), C. albicans I/P. 3rd group was injected with (0.5)ml of sterile normal saline I/p. The results showed that the immunized animals revealed cellular immune response, negative fungal isolates and minor pathological changes in compared with positive control. Positive control animals show severs fungal isolates from internal organs with sever pathological changes characterized mainly by polymorphonuclear cells infiltration and multiple foci of granulomatous lesion.
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