THE EFFECT OF AQUEOUS AND ALCOHOLIC EXTRACT OF CYPERUS LONGOUS (CYPERACEAE) AND TOW DRUGS (TINIDAZOLE AND PRAZIQUANTEL) ON KILLING THE PROTOSCOLICES OF ECHINOCOCCUS GRANULOSUS IN VITRO.
2009
Fatin Abdul.Jabbar-Mustafa
The protoscolices of Echinococcus granulosus in vitro compared with the two drugs Tinidazole and Praziquantel using the concentrations (5 , 10 , 15 , 20) % of the plant extracts and (1.25 , 1.8 , 2.5) % for Tinidazole and (0.1 , 0.15 , 0.2) % for Praziquantel respectively. The study shows that the aqueous extract at 20% have showen highest protoscolicidal activity. All the protoscolices were killed in the first day after treatment. While the concentration 5% shows the lowest activity in killing the protoscolices which was in the 6th day , while the time of killing protoscolices was in the 3rd day and 2nd day at the concentration (10 , 15)% respectively. There is no significant differences between aqueous and alcoholic extract of Cyperus longous P< 0.01 , so aqueous extract used in our study because of its lower price and its safety. Tinidazole and Praziquantel have showen the great activity on killing the protoscolices in the 30 & 60 minutes at (2.5 , 0.2) % respectively. The preservative solution (Hankُ s solution). Keep the protoscolices viable 59% to 21 days.
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