THE HISTOPATHOLOGICAL CHANGES OF INHALATION OF TOLUENE IN RABBITS
2010
This study was designed to determine whether toluene abuse affected the organs function or general health of males and females. In this study used 24 rabbits of both sex , the animals were divided in four groups , six animals in each group ,the animals were exposed to toluene vapor inhalation ( 500 ppm / 2h/day ) daily for 2 months.Exposure –related suppression of body weight gain and food consumption were observed. Salivation and lacrimation were observed during exposure periods .The pathological changes these were showed organs have simple different between the males and females. The pathological changes observed in the lungs of males are emphysema, infiltration of lymphocytes in alveolar wall , thickness of alveolar wall ,and hemorrhage ,similar to that in female .The pathological changes observed in the kidney of females observed fatty degenera- tion and cloudy swelling ,while in the males cloudy swelling only. The pathological changes observed in the liver of females observed hydropic degeneration , while in the liver of males hydropic degeneration , congestion of blood vessels ,and infiltration of inflammatory cells (lymphocytes).The pathological changes observed in the uterus of females observed fibrosis, oedema , degeneration of the cells lining the uterine gland ,and red blood cells with inflammatory cells.
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