STUDY THE PROTECTIVE ROLE OF QUERCETIN AGAINST O-ANISIDINE TOXICITY ON SOME HEMATOLOGICAL PARAMETERS OF LABORATORY MALE RATS (RATTUS NORVEGICUS).
2015
Wissam Sajid Al-Uboody | Muhammed Ali Al-Diwan
The study was designed to assess the protective role of Quercetin against Oanisidine toxicity. 24 male rats (Rattus norvegicus) were used and divided into 3 equal groups of 8 male rats each. The first group was the control group in which the animals were fed on a standard ration for 15 days, then they were terminated. The second group was fed on a ration contains 1000mg/kg O-anisidine hydrochloride for 15.The third group was fed on a ration contains 1000mg/kg O-anisidine hydrochloride + 80mg/kg Quercetin dihydrate for 15. The results revealed that the treatment with Oanisidine hydrochloride for 15 days (1rst treated group) caused significant decrease in the R.B.C. count, Hb concentration, P.C.V. percentage, neutrophil and lymphocyte counts and it caused significant increase in platelets count, total leukocytes, monocytes, eosinophil and basophil counts, as compared with control group. When Quercetin dihydrate was offered as a protective agent in the ration of the 2nd treated group, it showed a significant ameliorating effect by increasing the R.B.C. count, Hb concentration, P.C.V. percentage, neutrophil and lymphocyte counts and it caused significant decrease in platelets count, total leukocytes, monocytes, eosinophil and basophil counts, as compared with the 1rst treated group. For the blood indices (RDW, MCH, MCHC, MCV, and MPV) there were no significant differences among all the experiment groups except for the mean platelet volume (MPV), where Oanisidine hydrochloride caused significant decrease in the MPV of the 1rst treated group as compared with control and 2nd treated group at (P≤0.05).
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