COMPARATIVE STUDY OF HYPOCHOLESTEROLEMIC EFFECT ON TAURINE ANDSIMVASTATIN IN MALE RATS
2016
Hanadi Al_hilfi | Ahlam Al-Rekabi | Wasfi Al- Masoudi | kamal alsaad | Abdulkadhim Aneed | Karima Al-Salihi | Ali Ajeel | Kasim Hussein Ali | Iman AlShati | Najlaa Ibrahim | Nadhim Jakhsi | Gahin Taib | Mahdi Abdullah | Rizgar Nabi | Nameer A.Kareem Al zubaidi | Mortadha Salh Hatim
This study was conducted to investigate the effect of Taurine as hypocholesterolemic agentand compare with the results of simvastatin drug on male rats. The experiment consisted of 36adult male rats (Rattus norvegicus) weighting range 170 -200 gm divided into six groups (six foreach), the control group were fed on standard ration for four weeks while cholesterol group fedon standard ration and (10gm/kg/ration) cholesterol. The third group treated by taurine(0.7mg/day/rat) in drinking water while fourth group treated by simvastatin (0.05 mg/day/rat) indrinking water during animal fed on cholesterol in standard ration for 4 weeks. The fifth and sixgroup animals fed standard ration and cholesterol for 4 weeks and then treated with taurine andsimvastatin (0.7 mg and 0.05 mg /day/rat) in drinking water for 4 weeks respectively.At the end of study, the rats were sacrificed and blood serum was collected .The evaluation oftotal cholesterol, LDL-cholesterol, VLDL- cholesterol, HDL- cholesterol and triglyceride weredone and also AST and ALT were measured.The results revealed there were a significant decreasing in the lipid profile parameters (TC, TG,LDL-C and VLDL-C) and noted there were a significant increasing in HDL-C parameter oftaurine treated group and simvastatin treated group when compared with control and highcholesterol groups. Taurine showed better effect on hepatic enzyme activities and lipid profileparameters when compared with simvastatin treated groups.
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