COMPARATIVE STUDY BETWEEN THE ROLE OF THE GRAVIOLA AND ETHANOLIC EXTRACT OF Eucalyptus camaldulensis ON HEPATIC REGENERATION IN RABBITS MODEL
2018
Firas Hussain al-baw. | Zainab J. Malik | A. J. AL- Khamas
The aim of this study was to investigate the effect of graveola and extract ofeucalyptus productions on liver regeneration. 16 mature males rabbit were used. Theanimals were divided into two equal groups. The animals were anesthetized byketamine and xylazine as general anesthesia. The animals were anesthetized byatropine sulphate (1mg /Kg B.W) intramuscularly as premedication and 15 minuteslater a mixture of xylazine hydrochloride (20mg /Kg B.W) and Ketaminehydrochloride (40 mg /Kg B.W) intramuscularly. After anesthetized the rabbits andpreparation the site of operation was done in the upper part of abdomen, then Surgicalincision was done and exposure of fourth lobe of the live. The liver handling bythump forceps and the stitches was done on the lobe. Three knots were tied anddissecting scissors were used to cut the tied lobe just distal to the suture. Then theabdominal wall was approximated with a running 3-0 Polyglactin suture, and theskin was closed with a running 2-0 polyamide suture. And after hepatoctomy dividedthe animals to two equal groups; first group give the graveola orally and second groupgive the extracted eucalyptus orally too for 15 days . The clinical parameters includedtemperature, respiratory , and heart rates, were within acceptable limits postoperatively in all animals in two groups. The intra-abdominal adhesions in differentdegrees of evaluations and occurred among liver, different organs and abdominal wallthat more frequency in graviola group when compared with another treated group.Histopathological Examinations was done by taken the liver biopsies on 15th day postoperatively. The histopathological results of this study revealed that the liver regeneration similar maturity in two groups
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