AMELIORATIVE ROLE OF SCHIFF-BASE DERIVED FROM PHENYL ETHYL AMINE AGAINST SODIUM NITRATE TOXICITY IN LABORATORY MALE RATS
2020
Ibtihal Hassan Hatim | Rashad Fadhil Ghadhban | Wasfi Aboud Al-Masoudi
This study was designed to Evaluate the biological activity of Schiff base derived fromphenyl ethyl amine produced novel compound used in this experiment. Thirty adult male ratsage (10-14) weeks (150-200) gm weights were included and separate randomly into 5 groups (6rats / group) and treated for 21days intraperitoneally (I.P) as follows:- Group 1 (control):0.5ml/day of DMSO daily ,Group 2: 18mg/kg of NaNO2, daily ,Group 3 94 mg/kg of phenylethyl amine daily ,Group 4 18 mg/kg of NaNO2, then after one hour 0.5ml/day from 66.8mg/kgof synthesis compound daily , Group 5: 0.5ml/day from 66.8mg/kg of synthesized compound.According to finding Results there was significant ameliorative effects of Schiff base againstsodium nitrate toxicity in several physiological parameters as (R.B.C. count , Hb. concentration ,PCV. ,W.B.C. count MID%, TSH,T3 andT4 levels ) which the result showed there weresignificant decreased in this parameters in group 5 where administrate sodium nitrate and afterone hour novel compound in compared with group 2 sodium nitrate alone .
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