EFFECT OF SODIUM FLUORIDE ON SOME PHYSIOLOGICAL PARAMETERS AND HISTOPATHOLOGY IN ADRENAL AND THYROID GLANDS IN ADULT MALE RATS
2020
Marwa Adel Hameed | Bader Khatlaan Hameed | Khalid Ahmed Hadi
This study was carried out to investigate the harmful effect of water fluoridation on both(thyroid and adrenal gland) in adult male rats its weight about (400-300gm) exposed to sodiumfluoride(NaF) in the drinking water. We are used in this study (٣٠) adult male rats (albino) weredistributed randomly and divided into two equal groups (15 animals per group) . The first groupwas given normal water and considered as a control group (control group), while the second groupwere given drinking water with 100 ppm of sodium fluoride(NaF) (treated group). this study carriedout in the animal house in the college of Vet. Med.\ Tikrit University. blood was drawn through theeye pupil for periods (0,30,60 days) in order to measure the following parameters: Measurement ofGlutathione(GSH) concentration, total cholesterol and blood glucose concentration . In additiontaking tissue sections of the thyroid and adrenal glands.The results of this study showed thatexposure of animals to sodium fluoride at a concentration of 100 ppm in drinking water for (60)days cause adrenal and thyroid gland dysfunction, represented by a significant decrease in the levelof glutathione in blood serum on days 30 and 60 of the experiment and a significant increase in totalcholesterol and blood glucose concentrations.The results of the histological examination of thethyroid gland of the treated group showed hyperplasia of the epithelial cell layer lining the acini vesicles, and severe lipid changes were seen in the function of Reticularis in the histological sections of the thyroids gland of the same group animals. The results of this study confirmed theharmful effect of sodium fluoride(NaF) on thyroid and adrenal functions in addition to its effect onsome biochemical parameters that are indicative of the occurrence of harmful effects of somechemical compounds
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