Astroglial CB 1 Reveal Sex‐Specific Synaptic Effects of Amphetamine
2025
Mariani, Yamuna | Dalla-Tor, Tommaso | Garavaldi, Tommaso | Julio-Kalajzić, Francisca | Gisquet, Doriane | Gomez‐sotres, Paula | Cannich, Astrid | Gambino, Giuditta | Drago, Filippo | Serrat, Roman | Hurel, Imane | Chaouloff, Francis | Pouvreau, Sandrine | Bellocchio, Luigi | Marsicano, Giovanni | Covelo, Ana | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB) ; Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM) | Università degli studi di Palermo - University of Palermo (UNIPA) | Università degli studi di Catania = University of Catania (Unict) | Nutrition et Neurobiologie intégrée (NutriNeuro) ; Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Physiopathologie du système nerveux central - Institut François Magendie ; Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM) | Centre National de la Recherche Scientifique (CNRS) | ANR-10-LABX-0043,BRAIN,Bordeaux Region Aquitaine Initiative for Neuroscience(2010)
International audience
Afficher plus [+] Moins [-]anglais. ABSTRACT The Nucleus Accumbens (NAc) is a critical brain region for the effects of psychostimulant drugs. Type‐1 cannabinoid receptors (CB 1 ), the main elements of the endocannabinoid system (ECS) in the brain, participate in these effects and modulate synaptic functions in the NAc. Besides their neuronal expression, CB 1 receptors are also present in astrocytes, where they contribute to the regulation of synaptic plasticity and behavior. However, the impact of astroglial CB 1 receptors on synaptic plasticity in the NAc and on psychostimulant‐induced synaptic and behavioral effects is currently unknown. This study shows that the psychostimulant amphetamine impairs a form of astroglial CB 1 receptor‐dependent synaptic plasticity in the NAc of male, but not female mice. Consistently, locomotor effects of amphetamine require astroglial CB 1 receptors in male, but not female mice. These results, by revealing unforeseen mechanisms underlying sex‐dependent effects of amphetamine, pave the way to a better understanding of the diverse impact of psychostimulants in women and men.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Institut national de la recherche agronomique
Découvrez la collection de ce fournisseur de données dans AGRIS