Exploring the Relationship Between Inflammatory Cytokines and PCOS Development: A Cross-Sectional Analysis
2025
Apoorva Jain | Jagadeesha Pooya | Asha Neravi | Sunil Kumar K.S | Ajay Kumar Oli
Polycystic Ovary Syndrome (PCOS) is a common reproductive disorder with global prevalence, affecting women from adolescence to post-menopause. This study investigates the association between PCOS and cytokine levels to understand the inflammatory aspects of the condition. The research involved 30 PCOS cases and 30 BMI-matched healthy controls. Clinical assessments, including hormonal, biochemical, and anthropometric parameters, were conducted alongside cytokine analysis using Quantitative Real-time PCR (qRTPCR). The results revealed significant differences in age, waist circumference, and hormonal markers between the PCOS and control groups. The study identified correlations between cytokine levels and clinical parameters, providing insights into the immune and inflammatory aspects of PCOS. The ROC analysis demonstrated the discriminatory potential of IL-5 in distinguishing PCOS from healthy subjects. The heat map and clustering analysis further elucidated the interplay of cytokines, hormonal markers, and clinical parameters associated with PCOS. This comprehensive investigation enhances our understanding of the pathophysiology of PCOS and highlights potential biomarkers for diagnostic and therapeutic purposes.
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