Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.
2023
Scaramuzzo, G | Nucera, F | Asmundo, A | Messina, R | Mari, M | Montanaro, F | Johansen, MD | Monaco, F | Fadda, G | Tuccari, G | Hansbro, NG | Hansbro, PM | Hansel, TT | Adcock, IM | David, A | Kirkham, P | Caramori, G | Volta, CA | Spadaro, S
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
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