Embryotoxicity, mutagenicity and teratogenicity study of a drug for external use based on birch tar on white rats
2024
M. B. Kychan
The article presents the results of the study of embryotoxicity, mutagenicity and teratogenicity of the veterinary drug “Kubazol” on white rats. The drug “Kubazol” is a spray for external use, solution. 1 ml of the drug contains the active ingredient: birch tar – 40,0 mg. Excipients: ethyl acetate, polybutyl methacrylate. The veterinary medicinal product is used for dogs: treatment of animals for skin lesions (wounds, dermatitis, eczema), claw lesions (superficial panaritium, etc.), postoperative treatment of claws. Horses (sports): treatment of animals for hoof diseases (corneal arrow suppuration, superficial panaritium), postoperative treatment of hooves. As a result of the conducted studies, it was found that when applying the drug “Kubazol” (spray for external use, solution) to the skin in doses of 1.0 and 5.0 ml/kg of body weight to pregnant female rats, the indicators of total and pre- and post-implantation embryonic lethality did not have significant differences compared to the indicators in the control. Applying the drug to the skin of pregnant females also did not affect the weight of the fetuses and their cranio-caudal size. In addition, no cases of fetal anomalies were found, which indicates the absence of embryotoxic and teratogenic effects of the drug “Kubazol” (spray for external use, solution) after application to the skin of pregnant female rats. Further studies will focus on studying the mutagenic effects of tar components on animal cells using standard tests such as the Ames test, the micronucleus test, as well as the analysis of chromosomal aberrations and conducting studies to study the effects of tar residues on the environment and possible mutagenic risks for biota.
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