Methanolic Phoenix dactylifera L. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats
2022
Heba Nageh Gad El-Hak | Hany Salah Mahmoud | Eman A. Ahmed | Heba M. Elnegris | Tahany Saleh Aldayel | Heba M. A. Abdelrazek | Mohamed T. A. Soliman | Menna Allah I. El-Menyawy
This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180&ndash:200 g) were allocated into four groups: control: date flesh (DF) group (oral 600 mg/kg MDFE for 21 days): Cis group (7.5 mg/kg i.p. at day 16): and date flesh/cisplatin (DF/Cis) group (oral 600 mg/kg MDFE for 21 days and 7.5 mg/kg i.p. at day 16). Hepatic biochemical parameters in sera, and inflammatory and oxidant/antioxidant hepatic biomarkers were estimated. Hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-&kappa:B), and alpha smooth muscle actin (&alpha:-SMA) were assessed. Pretreatment with MDFE decreased Cis-triggered liver biochemical parameters, oxidative stress, inflammatory biomarkers, and histological damage. Moreover, MDFE treatment reduced Cis-induced hepatic NF-&kappa:B, COX-2, and &alpha:-SMA protein expression. MDFE exerted a hepatoprotective effect when used concomitantly with Cis. Its effect was mediated via its antioxidant and anti-inflammatory ingredients.
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