Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
2025
Davidson, S. M. | Andreadou, I. | Antoniades, C. | Bartunek, J. | Basso, C. | Brundel, Bjjm | Byrne, R. A. | Chiva-Blanch, G. | Costa Martins, P., Da | Evans, P. C. | Girão, H. | Giricz, Z. | Gollmann-Tepeköylü, C. | Guzik, T. | Gyöngyösi, M. | Hübner, N. | Joner, M. | Kleinbongard, P. | Krieg, T. | Liehn, E. | Madonna, R. | Maguy, A. | Paillard, M. | Pesce, M. | Petersen, S. E. | Schiattarella, G. G. | Sluijter, J. P. G. | Steffens, S. | Streckfuss-Bömeke, K. | Thielmann, M. | Tucker, A. | van Linthout, S. | Wijns, W. | Wojta, J. | Wu, J. C. | Perrino, C. | The Hatter Cardiovascular Institute (THCI) ; University College of London [London] (UCL) | University College of London [London] (UCL) | National and Kapodistrian University of Athens (NKUA) | University of Oxford | department organization Studies ; Boston College (BC) | Azienda Ospedale Università di Padova = Hospital-University of Padua (AOUP) | Amsterdam University Medical Centers (Amsterdam UMC) | Vrije Universiteit Amsterdam [Amsterdam] (VU) | cardiovascular Research Institute Dublin, Ireland. | Universitat Oberta de Catalunya [Barcelona] (UOC) | August Pi i Sunyer Biomedical Research Institute [Barcelona] | Instituto de Salud Carlos III [Madrid] (ISCIII) | Maastricht University [Maastricht] | William Harvey Research Institute, Barts and the London Medical School | Queen Mary University of London (QMUL) | Universidade de Coimbra = University of Coimbra [Portugal] (UC) | Coimbra Institute for Clinical and Biomedical Research [Coimbra, Portugal] (iCBR - Faculty of Medicine) ; Universidade de Coimbra = University of Coimbra [Portugal] (UC) | Semmelweis University [Budapest] | Innsbruck Medical University = Medizinische Universität Innsbruck (IMU) | The University of Edinburgh | Medizinische Universität Wien = Medical University of Vienna | Max Delbrück Centrum für Molekulare Medizin (MDC) | Charité - UniversitätsMedizin = Berlin University Medicine | German Heart Center = Deutsches Herzzentrum München [Munich, Germany] (GHC) | Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen) | Addenbrooke's Hospital ; Cambridge University NHS Trust | University of Southern Denmark (SDU) | University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] (UniPi) | Universität Bern = University of Bern = Université de Berne (UNIBE) | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) ; Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Centro Cardiologico Monzino [Milano] ; Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO) ; Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) | Barts Heart Centre [London, UK] (St Bartholomew’s Hospital) ; Barts Health NHS Trust [London, UK] | University of Naples Federico II = Università degli studi di Napoli Federico II | German Center for Cardiovascular Research (DZHK) ; Berlin Institute of Health (BIH) | Max Delbrück Center for Molecular Medicine [Berlin] (MDC) ; Helmholtz-Gemeinschaft = Helmholtz Association | Utrecht Brain Center [UMC] ; University Medical Center [Utrecht] (UMCU) | University Medical Center [Utrecht] (UMCU) | Universiteit Utrecht / Utrecht University [Utrecht] | Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München (LMU) | University Hospital of Würzburg | University Medicine Göttingen | West German Heart Center ; Universität Duisburg-Essen = University of Duisburg-Essen [Essen] | Barts Health NHS Trust [London, UK] | Berlin Institute of Health (BIH) | Charité Campus Virchow-Klinikum (CVK) | National University of Ireland [Galway] (NUI Galway) | Stanford Cardiovascular Institute
International audience
Afficher plus [+] Moins [-]anglais. Animal models offer invaluable insights into disease mechanisms but cannot entirely mimic the variability and heterogeneity of human populations, nor the increasing prevalence of multi-morbidity. Consequently, employing human samples-such as whole blood or fractions, valvular and vascular tissues, myocardium, pericardium, or human-derived cells-is essential for enhancing the translational relevance of cardiovascular research. For instance, myocardial tissue slices, which preserve crucial structural and functional characteristics of the human heart, can be used in vitro to examine drug responses. Human blood serves as a rich source of biomarkers, including extracellular vesicles, various types of RNA (miRNA, lncRNA, and circRNAs), circulating inflammatory cells, and endothelial colony-forming cells, facilitating detailed studies of cardiovascular diseases. Primary cardiomyocytes and vascular cells isolated from human tissues are invaluable for mechanistic investigations in vitro. In cases where these are unavailable, human induced pluripotent stem cells serve as effective substitutes, albeit with specific limitations. However, the use of human samples presents challenges such as ethical approvals, tissue procurement and storage, variability in patient genetics and treatment regimens, and the selection of appropriate control samples. Biobanks are central to the efficient use of these scarce and valuable resources. This scientific statement discusses opportunities to implement the use of human samples for cardiovascular research within specific clinical contexts, offers a practical framework for acquiring and utilizing different human materials, and presents examples of human sample applications for specific cardiovascular diseases, providing a valuable resource for clinicians, translational and basic scientists engaged in cardiovascular research.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Institut national de la recherche agronomique
Découvrez la collection de ce fournisseur de données dans AGRIS