Twisting development, the birth of a potential new gene
2022
Marsch-Martínez, Nayelli | Reyes-Olalde, J. Irepan | Chalfun-Junior, Antonio | Bemer, Marian | Durán-Medina, Yolanda | Ochoa-Sánchez, Juan Carlos | Guerrero-Largo, Herenia | Herrera-Ubaldo, Humberto | Mes, Jurriaan | Chacón, Alejandra | Escobar-Guzmán, Rocio | Pereira, Andy | Herrera-Estrella, Luis | Angenent, Gerco C. | Delaye, Luis | Folter, Stefan de
Evolution has long been considered to be a conservative process in which new genes arise from pre-existing genes through gene duplication, domain shuffling, horizontal transfer, overprinting, retrotransposition, etc. However, this view is changing as new genes originating from non-genic sequences are discovered in different organisms. Still, rather limited functional information is available. Here, we have identified TWISTED1 (TWT1), a possible de novo-originated protein-coding gene that modifies microtubule arrangement and causes helicoidal growth in Arabidopsis thaliana when its expression is increased. Interestingly, even though TWT1 is a likely recent gene, the lack of TWT1 function affects A. thaliana development. TWT1 seems to have originated from a non-genic sequence. If so, it would be one of the few examples to date of how during evolution de novo genes are integrated into developmental cellular and organismal processes.
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