Decision making for sustainable development must be reviewed based on the new insights into Infection and immunity and the impacts of mathematical modeling on vaccination and disease control. Regarding to important role of immune genes in disease resistance and controlling production traits, immunogenetics parameters should be considered in modeling for disease control. Investigating the polymorphism as well as associations and linkages to traits in native animals, as a genetic resource of our country, would be worthwhile and can be used in future native breeding programs.Decision making for sustainable development must be reviewed based on the new insights into Infection and immunity and the impacts of mathematical modeling on vaccination and disease control. Regarding to important role of immune genes in disease resistance and controlling production traits, immunogenetics parameters should be considered in modeling for disease control. Investigating the polymorphism as well as associations and linkages to traits in native animals, as a genetic resource of our country, would be worthwhile and can be used in future native breeding programs.