This work was carried out to study the effect of using some natural dietary supplements; i.e. powders of date palm pits and pollen, ginseng roots, moringa leaves and royal jelly which giving orally in capsule to improve endurance of weightlifter athletes throughout 12 weeks in camp of sport Championship Sector belongs to the Armed Forces, Ministry of Defense, Future City, Cairo, Egypt. Collecting data showed that the suggested dietary supplement capsule had the highest value of the antioxidant activity (96.3%) and significant increases in total phenolic and flavonoids content (52.42 & 63.1 mg/g, respectively). Also, the anthropometric measurements showed a significant increase in weight and height in males compared to females. likewise, waist and mid upper arm circumference had significant increases in males compared to females, Male weightlifter athletes had significant muscles mass bigger than female one, and the fat mass for male was assessed as ‘‘Fitness’’ which ranged between (14 and 17%) but the female had fat mass that assessed as ‘‘Athletes’’ which ranged between (14 and 20%). The weights lifting by male and female increased during three months, and also revealed a significant increase in the efficiency of males in lifting weights higher than in the females during the period of 12 weeks. Thus, the results indicated that by incorporating natural dietary supplement powders in suggesting capsule, it is possible to enhance the performance of weightlifter athletes.