Liver fluke are common parasites of herbivores in most of Middle East countries as Egypt. The chronic and acute infections with 10 & 20 metacercaria of this parasite cause biliary liver cirrhosis in rabbits that lead to huge economic losses. This cross-sectional study was carried out to determine the prevalence of fascioliosis in slaughtered rabbits in Giza governorate. In Egypt Fasciola gigantica was responsible for V-Line and Black Baladi rabbits total liver condemnations in infected groups. The infection impacts on female rabbits were more than males (p<.0001) in most groups for both strains.  Liver condemnations due to fascioliasis were more affected in body weight and feed consumption, feed conversion, heart, kidney and carcass characterestic, so it`s low economic efficiency. Blood parametars showed high significant (p<.0001) between treated groups of strains.