Copper has been known to possess antimicrobial properties since as far back as the Phoenician era where ship hulls were copper sheathed to prevent the inevitable effects of biofouling. As a consequence of evolving scientific research and development, therealization of novel materials and agents has enabled new scientific branches, such as nanotechnology. In this paper, we investigate the performance of different forms of copper coating for application as antifouling materials. Samples were deployed in Tuticorin-Newharbour for four weeks and analyzed for evidence of biofouling. It was found that copper in its nanoform, produced the greatest antifouling effectiveness in mild steel compared to other forms ofantifouling coating.