Data on studying of efficiency of application of immunobiological preparations on efficiency and other clinical and biochemical indicators for chickens-broilers are cited. It is established, that their application to chickens-broilers promotes increase of biological value of fowl as foodstuff and is economically expedient. Application of a preparation the Biococktail-NK in an optimum dose 0,1 - 0,2 ml/goal (10,0-20,0 million microbic bodies) has allowed to increase intensity of growth of chickens-broilers by 3,5%, to lower forage expenses for production of a gain of body weight of 1 kg on 4,95%, to raise safety of young growth of birds on 3,4 % and to lower a case of birds to 1,6% (technological norm of 5%). The carried out calculations have shown, that introduction of the Biococktail-NK in a ration of broilers is economically justified, as safety of young growth in 4th trial group has raised on 3,4%, in the third - on 2,5%, in the second - on 1,3%. On the basis of the spent research fowl of the delivered samples in which ration it was entered the probiotic Biococktail-NK from calculation 0,1 - 0,2 ml/goal (10,0-20,0 million microbic bodies) since daily age within the first 5 days into 4 cycles with an interval of 7 days till the end of the cultivation period is established, that on organoleptic, physical and chemical, bacteriological indicators, and also biological value and harmlessness does not concede to meat of control group and is good-quality. In the literature there are data about influence of biologically active substances on growth and development of bird. Despite it, about influence of probiotical and immunostimulatory preparations as separately, and in a complex with probiotics, on an organism of chickens-broilers it is not enough data that induces carrying out of scientific research in the given direction. Simultaneous use of probiotics on the basis of an intestinal stick in rations of chickens-broilers is the perspective directions. Proceeding from it, working out of new effective ways of increase of chickens-broilers efficiency with a view of reception of ecologically pure and safe products of poultry farming is actual for poultry-farming economy of Belarus.

Comparative evaluation of the influence of cell-free probiotic preparation Laktimet and cellular probiotic Bifilak on productivity, livability, nonspecific response of suckling piglets in the early extrauterine life was realized in the conditions of the Republic of Belarus.Application of both probiotics increased the productivity of suckling pigs, stimulated the processes of metabolism and natural protection of organism in the early postnatal period in the conditions of specialized pig breeding complexes. Research results showed, that application of brand new cell-free probiotic Laktimet exercised higher influence on suckling pigs. Application of Laktimet made it possibler to increase piglets body weight gain on 7,8%; piglet livability - on 6,7%; and application cellular probiotic preparation Bifilak - on 5,4% and 3,3%, respectively. The same tendency was noted during the analysis of indexes of cellular factors of organism protection. Bactericidal activity of blood serum of experimental animals changed both in connection with age, and under influence of probiotic preparations. During all studied periods the bactericidal activity of blood serum was authentically (P less than 0,05) above in experimental groups in comparison with a control group. At 20-days old piglets there was stated the strengthening of bactericidal activity of blood serum. Throughout all period of experiment the superiority of trial animals over control on indicators of lysozyme activity of blood serum was observed

The effectiveness of stress prevention with use of sedative remedy Xyla in a complex with preparations Ascorbic acid with glucose, Aesel and Katosal, which improve adaptation, was researched. Application of a complex of neurotropic and adaptogenic preparations before and after dehorning promoted softening of stressful influence, that in turn has positively affected the general condition of animals and intensity of growth. Comparative test of four schemes of preventive maintenance of negative consequences of the stress caused calf dehorning, has shown their high efficiency. However more expressed stimulating influence on intensity of metabolism, antioxidant status, natural resistance, adaptation to action of stresses-factors and rates of a body weight gain were rendered by the scheme with use of preparations Aesel, Ascorbic acid with glucose and Ksila

The purpose of the research was establishment of hepatic diseases spread in cattle fattening. Trials were conducted with total number of hybrids IV-V generation of black-motley heifer with pedigree Hereford bulls. It has been established the wide spread (22,4%) of hepatic pathology. The leading place among all hepatic pathologies belongs to fatty hepatosis (13,4%) with weakly expressed symptoms, decrease of serum protein level, albumin, glucose and increase of bilirubin, globulins, hepatic enzymes and strong pathology-anatomical and histological manifestations. In the tabular form results of histologic research of liver, some biochemical indicators of blood of healthy and sick animals (M +/- m), the clinical symptoms revealed during the various periods are resulted | Целью исследований являлось изучение структуры и установление широты распространения болезней печени у крупного рогатого скота на откорме. Опыты проведены на широком поголовье помесей IV-V поколения тёлок чёрно-пёстрой породы с племенными быками герефордской породы. Установлено широкое (22,4%) распространение гепатопатий. Ведущее место среди различных форм поражения печени принадлежит жировому гепатозу - 13,4%, морфофункцинальный профиль которого определяется слабо выраженными клиническими симптомами, уменьшением уровня общего белка, альбуминов, глюкозы, повышением концентрации билирубина, активности гепатоспецифических ферментов, а также всех фракций глобулинов, яркой и характерной патологоанатомической и гистологической картиной. В табличной форме приведены результаты гистологического исследования печени, некоторые биохимические показатели крови здоровых и больных животных (M +/- m), клинические симптомы, выявленные в различные периоды

Determination of the efficiency of young fat stock feeding with wet rolled maize grain which was preserved by means of different preparations was realized in the conditions of the Republic of Belarus. The following preserving agents were applied: HV-2 (by- product of amino-formaldehyde resin); AIV 3 Plus (mixture of 62% formic acid and 24% ammonium formate; KEMIRA, Finland); carbamide (30 kg/t) with 40 g/t of complex mineral supplement. Feeding of young fat stock with rolled maize grains preserved by NV-2 promoted the increasing of nutrient digestibility on 1,5-5,0%, nitrogen use - on 2% in comparison with control. Application of rolled maize grain preserved with AIV-3Plus and carbamide with the complex mineral supplement made it possible to increase the digestibility of nutrients on 1,0-4,8% and nitrogen use - on 1,6-1,7%. Introduction of rolled maize grain preserved with NV-2 into rations of bull calves increased their productivity on 4,7% (P less than 0,05) with the simultaneous lowering of forage expenses on 1,9%. Application rolled maize grains preserved with AIV-3Plus made it possible to increase daily average weight gain on 3,8% and lower the forages expenses on 2,6%. Use preserved with NV-2 and AIV-3Plus rolled maize grains in rations of young fat stock lowered the production cost price on 11,9% and 10,8% that proved the efficiency of the studied fodder

Evaluation of maize (Zea mays) silage prepared in combination with biological preserving agent Laktotim and calculation of its economic efficiency were realized in the conditions of the Republic of Belarus. Application of Laktotim rendered positive influence on forage dry matter content, on nutritive substance safety, and made it possible to increase the organoleptic indicators of silage. Use of the maize silage prepared with the preservative in a cow ration has positively affected their dairy efficiency. Cow milk yields have raised on 4,5%. Application of the preparation for silage making of green maize mass proved to be economically worth. The realized toxicological estimation of biological preserving agent Laktotim did not reveal any signs of preparation toxicity. Introduction of the preparation into mice stomach in a single maximum dose (25000 mg/kg; 12500; 5000 mg/kg of body weight), as well as application of the preparation in mixture with water in ratio which in 100 and 200 times exceeded the standard ratio in plant green mass, did not cause destruction of experimental animals. According to classifications of All-Union State Standard 12.1.007-76, the preparation Laktotim belongs to the4 class of danger - low-hazardous substances (LD50 over 5000 mg/kg)

Nowadays in connection with an interdiction for antibiotics use in animal feeding it is very actual to work out and apply new forms of probiotic preparations which should be as ecologically safe and harmless both to people and animal products. Probiotics make it possible to improve the digestibility of nutritive substances of forages, normalize metabolism, enrich with biologically active substances that promotes the increasing of their productivity. In the Republic of Belarus the probiotics are produced in the obviously insufficient quantity that creates problems of young stock livability. Influence of application of Akozil and Sublicin probiotics in diets of suckling calves on biochemical parameters of blood serum was analysed. It was stated that use of the analysed probiotics made it possible to decrease the level of urea and total cholesterol, to increase of the total protein content in blood serum of the experimental calves. There was noted the increasing of glucose level in blood serum of calves fed with Akozil. There was marked the tendency of more optimal level of calcium and phosphorus in calves having Sublicin in their diets. The obtained results testified the normalization of metabolic processes taking place in calves which were fed by the mentioned above probiotics

There was realized the estimation of influence of application of biometals in a ration of chickens-broilers of different age on the content in their blood macro-and microelements. It is possible to make the conclusion, that in blood of chickens-broilers the tendency to decrease with the years concentration of calcium and magnesium, to increase of level of phosphorus, zinc and copper, and also increase the content of cobalt with 23-day age to 33-day and its insignificant decrease by 45 day of a life of chickens takes place. At the same time application in a ration of chickens-broilers of biometals sodium-ferrum-ethylenediaminetetraacetate (Na-Fe-etda) from calculation of 2,5 mg/kg, sodium-zinc-ethylenediaminetetraacetate (Na-Zn-etda) - 5,5 mg/kg, sodium-cobalt- ethylenediaminetetraacetate (Na-Co-etda) - 5,5 mg/kg and sodium-cuprum-ethylenediaminetetraacetate (Na-Cu-etda) - 3,5 mg/kg of body weight in the basic weight led to small increase of level macro- and microelements in blood of chickens-broilers and did not render negative influence on safety and a gain of body weight of chickens in trial group. Data on concentration of macro- and microelements in blood and a body weight gain of chickens-broilers are presented. | Целью работы является оценка влияния применения биометаллов в рационе цыплят-бройлеров разного возраста на содержание в их крови макро- и микроэлементов. Можно сделать заключение, что в крови цыплят-бройлеров имеет место тенденция к снижению с возрастом концентрации кальция и магния, повышению уровня фосфора, цинка и меди, а также увеличению содержание кобальта с 23-дненвного возраста к 33-дневному и незначительному снижению его к 45-му дню жизни цыплят. В то же время применение в рационе цыплят-бройлеров биометаллов натрий-ферум-этилендиаминтетраацетат (Na-Fe-etda) из расчета 2,5 мг/кг, натрий-цинк-этилендиаминтетраацетат (Na-Zn-etda) - 5,5 мг/кг, натрий-кобальт-этилендиаминтетраацетат (Na-Co-etda-) - 5,5 мг/кг и натрий-купрум-этилендиаминтетраацетат (Na-Cu-etda) - 3,5 мг/кг живой массы в основной своей массе приводило к небольшому повышению уровня макро- и микроэлементов в крови цыплят-бройлеров и не оказывало негативного воздействия на сохранность и прирост живой массы цыплят опытной группы. Представлены данные по концентрации макро- и микроэлементов в крови и прирост живой массы цыплят-бройлеров.

Analysis of the efficiency of application of fermented milk supplementary feed DKM (Belarus) produced on the basis of bacteria strain Lactobacilus acidophilus 55/06 in calve diets was realized in the conditions of the Republic of Belarus. Influence of feeding with acidified with the trial milk additive on forage palatability, biochemical blood structure and calve productivity was studied; economic efficiency of DKM use for processing of whole milk and its use in rations of calves was defined. Experimental batches of DKM fermented milk supplementary feed were produced at Grodno Medical Preparations Plant (Belarus). It was issued in the sterile corked polyethylene 5, 10 and 20 liter bottles or canisters. The fermented milk supplementary feed DKM could be stored at the temperature from 0 deg С up to 15 deg С. Shelf-life – 3 months from the moment of production. The additive represents the homogeneous mass of viscous consistence of cream color of various shades with a sour-milk smell. The carried out economic calculations showed, that as a result of growing capacity increase it animals of a trial group and reception of an additional total live weight gain there was stated the 6,5% decrease of expenses for fodder unit production in the experimental group. However, due to a high cost of acidified milk the cost of fodder unit in trial group was on 6,8% higher. As a result, the cost price of 1 kg weight gain in trial group (despite high additional weight gains) was stated at the level of control group. Application of fermented milk supplementary feed DKM in calve diets made it possible to lower calf disease incidence and to increase calf productivity on 11,8% without increasing the cost price of production

Studying of influence of various levels of selenium on growth, protein structure of blood serum, natural resistance, and reproductive performance of pedigree bull-calves was realized in the conditions of the Republic of Belarus. It was established, that feeding with an optimum dose of selenium (0,4 mg per 1 kg of dry matter) in rations of replacement bull-calves during the raising period promoted the increasing of daily average weight gain on 6,8%, indexes of natural resistance - on 0,5-13,9%, and sperm production quality - on 4,5-27,3%. In the conditions of optimization of selenium level of in diets the protein structure of blood serum of replacement bull-calves exceeded the similar index at control animals by the crude protein index - on 8,3 (Р less than 0,05), by albumine and alpha globulin -on 2,2% and 1,6%, respectively. Application of selenium in dose of 0,4 mg per 1 kg of dry matter made it possible to increase the indexes of natural resistance on 0,5-13,9%. Increase of selenium dose up to 0,4 mg per 1 kg of dry matter in made it possible to increase the quantity and quality of sperm of bull-calves, that was proved by the increasing of ejaculate volume on 4,5%, concentration of male germ cells in ejaculate – on 15,7% (Р less than 0,05) and male germ cells activity - on 7,3% (Р less than 0,001)